Balanced Crystalloids versus Saline in Critically Ill Adults-
SMART trial

A multicenter, randomized, controlled clinical trial of transfusion
requirements in critical care - TRICC Trial

Effects of tranexamic acid on death, vascular occlusive events,
and blood transfusion in trauma patients with significant
hemorrhage - CRASH-2 Trial

The North American Symptomatic Carotid Endarterectomy Trial -
NASCET

Open versus Endovascular Repair of Abdominal Aortic
Aneurysm

Claudication: Exercise Versus Endoluminal Revascularization
(CLEVER)

Minimally Invasive
Surgery

Minimally Invasive Versus Open Distal Pancreatectomy
(LEOPARD): A Multicenter Patient-blinded Randomized
Controlled Trial

Bariatric Surgery versus Intensive Medical Therapy in Obese
Patients with Diabetes: The STAMPEDE Trial

Cardiothoracic
Surgery

Synergy Between Percutaneous Coronary Intervention With
TAXUS and Cardiac Surgery - SYNTAX

Bypass Angioplasty Revascularization Investigation 2 Diabetes -
BARI 2D

General Surgical
Patient
Management

Trial of short-course antimicrobial therapy for intraabdominal
infection - STOP IT Trial

Small bites versus large bites for closure of abdominal midline
incisions (STITCH): a double-blind, multicentre, randomized
controlled trial - STITCH Trial

Intensive versus conventional glucose control in critically ill
patients - NICE-SUGAR Trial

Trauma,
Transfusion and
Surgical Critical
Care

Transfusion of plasma, platelets, and red blood cells in a 1:1:1 vs
a 1:1:2 ratio and mortality in patients with severe trauma -
PROPPR Trial

Ventilation with Lower Tidal Volumes as Compared with
Traditional Tidal Volumes for Acute Lung Injury and the Acute
Respiratory Distress Syndrome - ARMA Trial

Management of patients with anterior abdominal stab wounds: a
Western Trauma Association multicenter trial

A comparison of laparoscopically assisted and open colectomy
for colon cancer - COST Trial

Effect of Axillary Dissection vs No Axillary Dissection on 10-Year
Overall Survival Among Women With Invasive Breast Cancer
and Sentinel Node Metastasis - Z0011 Trial

Pylorus Preserving Pancreaticoduodenectomy Versus Standard
Whipple Procedure

A step-up approach or open necrosectomy for necrotizing
pancreatitis - Step Up Trial

Hartmann’s Procedure or Primary Anastomosis for Generalized
Peritonitis due to Perforated Diverticulitis: A Prospective
Multicenter Randomized Trial - DIVERTI Trial

Wait-and-see policy or laparoscopic cholecystectomy after
endoscopic sphincterotomy for bile-duct stones: a randomized
trial